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Alistair Boettiger, PhD, assistant professor of developmental biology, received a New Innovator Award, which provides up to $1.5 million over five years to fund innovative research by investigators who are within 10 years of their final degree or clinical residency and who have not yet received a research project grant or the equivalent from the NIH.
Boettiger’s research explores how genomes fold within a cell’s nucleus to affect gene expression.
“Like a book printed on origami, in which folding the pages changes the course of the story, the genomes of higher animals fold to connect or conceal different parts of this genetic blueprint to control cell behavior,” Boettiger said. “My lab is developing new microscopy approaches to observe this folding with detail never before achieved. This award will help us focus this technology on the developing embryos of diverse animal species to better understand the conserved mechanisms that shape genome organization and contribute to cell differentiation. It will also allow us to tap new genome-editing approaches to determine which sequences direct folding decisions.”
The ability to read and understand the distinct three-dimensional blueprints of a single cell will enable researchers to discern the links between an organism’s genome sequence, individual traits and the genetic aspects of health.
Boettiger is a National Academy of Sciences Kavli Fellow, a Beckman Young Investigator and a member of Stanford Bio-X.
Text link:: https://med.stanford.edu/news/all-news/2018/10/eight-scientists-awarded-nih-funds-for-high-risk-high-reward-research.html
A study at the Institute for Research in Biomedicine (IRB Barcelona) using Drosophila melanogaster has demonstrated that chromosomal instability itself can induce invasive behavior in epithelial cells and has identified the underlying molecular mechanisms involved.
Scientists have taken detailed pictures of the entire brain of an adult female fruit fly using transmission electron microscopy.
With what could lead to new insights on the workings of the brain as it ages, scientists say they have mapped the gene expression of each individual brain cell during aging in the fruit fly.
Reproductive stem cells of male fruit flies (Drosophila melanogaster) use a genetic trick to stay perpetually young across generations, according to new research published in the journal eLife.
New details of the molecular process by which our cells consume themselves point to therapeutic potential. Click link below to read more.
The Fly Media Center will not be operating during Stanford’s Winter Closure from Dec. 25th to Jan. 5th. Orders placed during this time will be made the week of Jan. 8th.
Because Will Adams will not be in today, orders for the week of 11/27 will be delayed by one day. Sorry for the inconvenience.